Please set up postfix properly before "makefml newml" can set up a ml. Set up /etc/postfix/main.cf like this: [/etc/postfix/main.cf] allow_mail_to_commands = alias,forward,include alias_maps = hash:/etc/mail/aliases hash:/var/spool/ml/etc/mail/aliases Please check that $mydestination contains the default domain (may be $mydomain). You need to edit /etc/postfix/main.cf to set up $virtual_maps. [/etc/postfix/main.cf] allow_mail_to_commands = alias,forward,include alias_maps = hash:/etc/mail/aliases hash:/var/spool/ml/etc/mail/aliases hash:/var/spool/nuinui.net/etc/mail/aliases virtual_maps = hash:/var/spool/nuinui.net/etc/postfix/virtual [/usr/local/etc/fml/ml_home_prefix] nuinui.net /var/spool/nuinui.net Both alias files and /var/spool/nuinui.net/etc/postfix/virtual are updated by makefml automatically where we suppose ml_home_prefix_maps defines nuinui.net /var/spool/nuinui.net relation. Postfix variable $mydestination should contain the default domain (may be $mydomain) but not virtual domain. Pay attention that we assume we use postfix style virtual domain. Please see postfix document for more details. When you begin to use a new virtual domain, you need to update both $alias_maps and $virtual_maps in /etc/postfix/main.cf. Also, you have to update /usr/local/etc/fml/ml_home_prefix by running "makefml newdomain". Recent postfix has $virtual_alias_maps and $virtual_maps variables. But $virtual_alias_maps = $virtual_maps by default. You can use either.